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Association between serum homocysteine level and cognitive function in middle-aged type 2 diabetes mellitus patients

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  • Johanda Damanik
  • Andre Mayza
  • Andhika Rachman
  • Rani Sauriasari
  • Melly Kristanti
  • Putri Syahida Agustina
  • Alexander Randy Angianto
  • Pukovisa Prawiroharjo
  • Em Yunir

Abstract

Type-2 diabetes mellitus (T2DM) is strongly associated with various complications, including cognitive impairment. Diabetic complication is related with structural and functional changes of brain. Studies investigated that homocysteine as an independent risk factor of several organ complications. This marker might have a role in pathogenesis of cognitive impairment in T2DM patients. We aimed to know the association between serum homocysteine level and cognitive impairment in middle-aged T2DM populations. The study was a cross-sectional study involving 97 T2DM patients aged

Suggested Citation

  • Johanda Damanik & Andre Mayza & Andhika Rachman & Rani Sauriasari & Melly Kristanti & Putri Syahida Agustina & Alexander Randy Angianto & Pukovisa Prawiroharjo & Em Yunir, 2019. "Association between serum homocysteine level and cognitive function in middle-aged type 2 diabetes mellitus patients," PLOS ONE, Public Library of Science, vol. 14(11), pages 1-11, November.
    • Handle: RePEc:plo:pone00:0224611
    DOI: 10.1371/journal.pone.0224611
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    References listed on IDEAS

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    1. Rafael Deminice & Diogo Farias Ribeiro & Fernando Tadeu Trevisan Frajacomo, 2016. "The Effects of Acute Exercise and Exercise Training on Plasma Homocysteine: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(3), pages 1-17, March.
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