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Cost-effectiveness analysis of aspirin for primary prevention of cardiovascular events among patients with type 2 diabetes in China

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Listed:
  • Minghuan Jiang
  • Pengchao Li
  • Joyce Hoi-sze You
  • Xinglong Zheng
  • Jizhao Deng
  • Mingyue Zhao
  • Liuxin Feng
  • Yu Fang

Abstract

The use of aspirin for primary prevention of cardiovascular disease (CVD) in patients with diabetes mellitus (DM) is associated with lower rates of cardiovascular events but increased risks of bleeding complications. We aimed to examine the cost-effectiveness of aspirin therapy for primary prevention of CVD in Chinese DM patients. A life-long Markov model was developed to compare aspirin therapy (100mg daily) versus no use of aspirin in DM patients with no history of CVD. Model validation was conducted by comparing the simulated event rates with data reported in a clinical trial. Direct medical costs and quality-adjusted life-years gained (QALYs) were the primary outcomes from the perspective of healthcare system in China. Sensitivity analyses were performed to examine the uncertainty of model inputs. Base-case analysis showed aspirin therapy was more costly (USD1,086 versus USD819) with higher QALYs gained (11.94 versus 11.86 QALYs) compared to no use of aspirin. The base-case results were sensitive to the odds ratio of all-cause death in aspirin therapy versus no use of aspirin. Probabilistic sensitivity analysis found that aspirin therapy gained an additional 0.066 QALYs (95% CI: -0.167 QALYs-0.286 QALYs) at higher cost by USD352 (95% CI: USD130-644)). Using 30,000 USD/QALY as willingness-to-pay threshold, aspirin therapy and no use of aspirin were the preferred option in 68.71% and 31.29% of 10,000 Monte Carlo simulations, respectively. In conclusion, aspirin therapy appears to be cost-effective compared with no use of aspirin in primary prevention of CVD in Chinese DM patients.

Suggested Citation

  • Minghuan Jiang & Pengchao Li & Joyce Hoi-sze You & Xinglong Zheng & Jizhao Deng & Mingyue Zhao & Liuxin Feng & Yu Fang, 2019. "Cost-effectiveness analysis of aspirin for primary prevention of cardiovascular events among patients with type 2 diabetes in China," PLOS ONE, Public Library of Science, vol. 14(12), pages 1-13, December.
    • Handle: RePEc:plo:pone00:0224580
    DOI: 10.1371/journal.pone.0224580
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    References listed on IDEAS

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    1. Zhan Wang & Jingjing Li & Chunxue Wang & Xiaomei Yao & Xingquan Zhao & Yilong Wang & Hao Li & Gaifen Liu & Anxin Wang & Yongjun Wang, 2013. "Gender Differences in 1-Year Clinical Characteristics and Outcomes after Stroke: Results from the China National Stroke Registry," PLOS ONE, Public Library of Science, vol. 8(2), pages 1-9, February.
    2. Chen-Wei Pan & Hong-Peng Sun & Hui-Jun Zhou & Qinghua Ma & Yong Xu & Nan Luo & Pei Wang, 2016. "Valuing Health-Related Quality of Life in Type 2 Diabetes Patients in China," Medical Decision Making, , vol. 36(2), pages 234-241, February.
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