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Sex-specific differences in risk factors of lymph node metastasis in patients with early gastric cancer

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Listed:
  • Eun Sook Ryu
  • Seung Jun Chang
  • Jungsuk An
  • Jun-Young Yang
  • Jun-Won Chung
  • Yoon Jae Kim
  • Kyoung Oh Kim
  • Dong Kyun Park
  • Kwang An Kwon
  • Seungyoon Nam
  • Woon Kee Lee
  • Jung Ho Kim

Abstract

Accurate prediction of lymph node status is of crucial importance in the appropriate treatment planning for patients with early gastric cancer (EGC). Some studies have examined factors predicting lymph node metastasis (LNM) in EGC; however, these studies did not consider sex-specific differences. This study aimed to investigate sex-specific differences in predictive risk factors of LNM in EGC based on surgical specimens. Patients who underwent surgical treatment for EGC between January 2003 and February 2016 were retrospectively evaluated. Patients who underwent previous gastric surgery or treatment for gastric neoplasms were excluded. Finally, 1076 patients treated for EGC were included in the analysis. We analyzed risk factors of LNM by dividing patients into male and female groups. Of 1076 patients (mean age 59.6 years), 69% were men. The overall LNM rate was 9.4%. The LNM rate was lower in men (7.8%) than in women (12.9%). Multivariate analysis showed that elevated type (odds ratio [OR], 2.084; 95% confidence interval [CI]: 1.053–4.125; P = 0.035), submucosal invasion (OR, 2.162; 95% CI: 1.018–4.595; P = 0.045), undifferentiated type (OR, 2.044; 95% CI: 1.107–3.772; P = 0.022), and lymphovascular invasion (LVI) (OR, 7.210; 95% CI: 3.835–13.554; P

Suggested Citation

  • Eun Sook Ryu & Seung Jun Chang & Jungsuk An & Jun-Young Yang & Jun-Won Chung & Yoon Jae Kim & Kyoung Oh Kim & Dong Kyun Park & Kwang An Kwon & Seungyoon Nam & Woon Kee Lee & Jung Ho Kim, 2019. "Sex-specific differences in risk factors of lymph node metastasis in patients with early gastric cancer," PLOS ONE, Public Library of Science, vol. 14(10), pages 1-11, October.
    • Handle: RePEc:plo:pone00:0224019
    DOI: 10.1371/journal.pone.0224019
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