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iCrotoK-PseAAC: Identify lysine crotonylation sites by blending position relative statistical features according to the Chou’s 5-step rule

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  • Sharaf Jameel Malebary
  • Muhammad Safi ur Rehman
  • Yaser Daanial Khan

Abstract

Among different post-translational modifications (PTMs), one of the most important one is the lysine crotonylation in proteins. Its importance cannot be undermined related to different diseases and essential biological practice. The key step for finding the hidden mechanisms of crotonylation along with their occurrence sites is to completely apprehend the mechanism behind this biological process. In previously reported studies, researchers have used different techniques, like position weighted matrix (PWM), support vector machine (SVM), k nearest neighbors (KNN), and many others. However, the maximum prediction accuracy achieved was not such high. To address this, herein, we propose an improved predictor for lysine crotonylation sites named iCrotoK-PseAAC, in which we have incorporated various position and composition relative features along with statistical moments into PseAAC. The results of self-consistency testing were 100% accurate, while the 10-fold cross validation gave 99.0% accuracy. Based on the validation and comparison of model, it is concluded that the iCrotoK-PseAAC is more accurate than the previously proposed models.

Suggested Citation

  • Sharaf Jameel Malebary & Muhammad Safi ur Rehman & Yaser Daanial Khan, 2019. "iCrotoK-PseAAC: Identify lysine crotonylation sites by blending position relative statistical features according to the Chou’s 5-step rule," PLOS ONE, Public Library of Science, vol. 14(11), pages 1-15, November.
  • Handle: RePEc:plo:pone00:0223993
    DOI: 10.1371/journal.pone.0223993
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    Cited by:

    1. Kuo-Chen Chou, 2020. "Showcase to Illustrate How the Web-Server iKcr-PseEns is Working," International Journal of Sciences, Office ijSciences, vol. 9(01), pages 85-95, January.
    2. Kuo-Chen Chou, 2020. "The pLoc_bal-mGneg Predictor is a Powerful Web-Server for Identifying the Subcellular Localization of Gram-Negative Bacterial Proteins based on their Sequences Information Alone," International Journal of Sciences, Office ijSciences, vol. 9(01), pages 27-34, January.

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