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Salivary molecular spectroscopy: A sustainable, rapid and non-invasive monitoring tool for diabetes mellitus during insulin treatment

Author

Listed:
  • Douglas C Caixeta
  • Emília M G Aguiar
  • Léia Cardoso-Sousa
  • Líris M D Coelho
  • Stephanie W Oliveira
  • Foued S Espindola
  • Leandro Raniero
  • Karla T B Crosara
  • Matthew J Baker
  • Walter L Siqueira
  • Robinson Sabino-Silva

Abstract

Monitoring of blood glucose is an invasive, painful and costly practice in diabetes. Consequently, the search for a more cost-effective (reagent-free), non-invasive and specific diabetes monitoring method is of great interest. Attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy has been used in diagnosis of several diseases, however, applications in the monitoring of diabetic treatment are just beginning to emerge. Here, we used ATR-FTIR spectroscopy to evaluate saliva of non-diabetic (ND), diabetic (D) and insulin-treated diabetic (D+I) rats to identify potential salivary biomarkers related to glucose monitoring. The spectrum of saliva of ND, D and D+I rats displayed several unique vibrational modes and from these, two vibrational modes were pre-validated as potential diagnostic biomarkers by ROC curve analysis with significant correlation with glycemia. Compared to the ND and D+I rats, classification of D rats was achieved with a sensitivity of 100%, and an average specificity of 93.33% and 100% using bands 1452 cm-1 and 836 cm-1, respectively. Moreover, 1452 cm-1 and 836 cm-1 spectral bands proved to be robust spectral biomarkers and highly correlated with glycemia (R2 of 0.801 and 0.788, P

Suggested Citation

  • Douglas C Caixeta & Emília M G Aguiar & Léia Cardoso-Sousa & Líris M D Coelho & Stephanie W Oliveira & Foued S Espindola & Leandro Raniero & Karla T B Crosara & Matthew J Baker & Walter L Siqueira & R, 2020. "Salivary molecular spectroscopy: A sustainable, rapid and non-invasive monitoring tool for diabetes mellitus during insulin treatment," PLOS ONE, Public Library of Science, vol. 15(3), pages 1-18, March.
    • Handle: RePEc:plo:pone00:0223461
    DOI: 10.1371/journal.pone.0223461
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    References listed on IDEAS

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    1. Paulo Mascarenhas & Bruno Fatela & Isabel Barahona, 2014. "Effect of Diabetes Mellitus Type 2 on Salivary Glucose – A Systematic Review and Meta-Analysis of Observational Studies," PLOS ONE, Public Library of Science, vol. 9(7), pages 1-15, July.
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