IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0223246.html
   My bibliography  Save this article

Genetic associations with radiological damage in rheumatoid arthritis: Meta-analysis of seven genome-wide association studies of 2,775 cases

Author

Listed:
  • Matthew Traylor
  • Rachel Knevel
  • Jing Cui
  • John Taylor
  • Westra Harm-Jan
  • Philip G Conaghan
  • Andrew P Cope
  • Charles Curtis
  • Paul Emery
  • Stephen Newhouse
  • Hamel Patel
  • Sophia Steer
  • Peter Gregersen
  • Nancy A Shadick
  • Michael E Weinblatt
  • Annette Van Der Helm-van Mil
  • Jennifer H Barrett
  • Ann W Morgan
  • Cathryn M Lewis
  • Ian C Scott

Abstract

Background: Previous studies of radiological damage in rheumatoid arthritis (RA) have used candidate-gene approaches, or evaluated single genome-wide association studies (GWAS). We undertook the first meta-analysis of GWAS of RA radiological damage to: (1) identify novel genetic loci for this trait; and (2) test previously validated variants. Methods: Seven GWAS (2,775 RA cases, of a range of ancestries) were combined in a meta-analysis. Radiological damage was assessed using modified Larsen scores, Sharp van Der Heijde scores, and erosive status. Single nucleotide polymophsim (SNP) associations with radiological damage were tested at a single time-point using regression models. Primary analyses included age and disease duration as covariates. Secondary analyses also included rheumatoid factor (RF). Meta-analyses were undertaken in trans-ethnic and European-only cases. Results: In the trans-ethnic primary meta-analysis, one SNP (rs112112734) in close proximity to HLA-DRB1, and strong linkage disequilibrium with the shared-epitope, attained genome-wide significance (P = 4.2x10-8). In the secondary analysis (adjusting for RF) the association was less significant (P = 1.7x10-6). In both trans-ethnic primary and secondary meta-analyses 14 regions contained SNPs with associations reaching P

Suggested Citation

  • Matthew Traylor & Rachel Knevel & Jing Cui & John Taylor & Westra Harm-Jan & Philip G Conaghan & Andrew P Cope & Charles Curtis & Paul Emery & Stephen Newhouse & Hamel Patel & Sophia Steer & Peter Gre, 2019. "Genetic associations with radiological damage in rheumatoid arthritis: Meta-analysis of seven genome-wide association studies of 2,775 cases," PLOS ONE, Public Library of Science, vol. 14(10), pages 1-12, October.
    • Handle: RePEc:plo:pone00:0223246
    DOI: 10.1371/journal.pone.0223246
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0223246
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0223246&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0223246?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0223246. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.