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Association of virological breakthrough and clinical outcomes in entecavir-treated HBeAg-positive chronic hepatitis B

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  • Yi-Jie Huang
  • Sheng-Shun Yang
  • Hong-Zen Yeh
  • Chi-Sen Chang
  • Yen-Chun Peng

Abstract

Background & aims: To evaluate virological breakthrough (VBT) and the risk of hepatocellular carcinoma (HCC) in HBeAg-positive chronic hepatitis B (CHB) patients receiving entecavir (ETV) treatment. Methods: A retrospective cohort study was conducted in a tertiary referral hospital and a total of 228 HBeAg-positive CHB patients treated with ETV for more than 48 weeks were enrolled. Clinical outcome measures included HBeAg seroclearance, maintained virological response and the development of HCC. Results: During a median follow-up period of 197 weeks, VBT developed in 26 (11.4%) patients (VBT group), and the other 202 patients without VBT (non-VBT group). The overall cumulative rate of HBeAg seroclearance in the VBT group and non-VBT group were 23.1% and 23.8%, 27.1% and 37.9%, 27.1% and 55.1%, 27.1% and 74.1%, 27.1% and 76.7% from week 48 to 240, respectively(p = 0.013). The cumulative probability of maintained virological responses from week 48 to 240 were 7.69% and 21.78%, 7.69% in the VBT groups and 36.85%, 7.69% and 51.68%, 7.69% and 64.97%, 7.69% and 72.1% in the non-VBT groups, respectively (p

Suggested Citation

  • Yi-Jie Huang & Sheng-Shun Yang & Hong-Zen Yeh & Chi-Sen Chang & Yen-Chun Peng, 2019. "Association of virological breakthrough and clinical outcomes in entecavir-treated HBeAg-positive chronic hepatitis B," PLOS ONE, Public Library of Science, vol. 14(8), pages 1-12, August.
    • Handle: RePEc:plo:pone00:0221958
    DOI: 10.1371/journal.pone.0221958
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