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Societal cost of oropharyngeal cancer by human papillomavirus status, cancer stage, and subsite

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  • Maria Silfverschiöld
  • Johanna Sjövall
  • Johan Wennerberg
  • Ellinor Östensson
  • Lennart Greiff

Abstract

Background: The incidence of oropharyngeal cancer (OPC) is increasing, particularly human papillomavirus (HPV)-associated OPC. The aim of this study was to specify the total societal cost of OPC by HPV status, cancer stage, and subsite using a bottom-up cost-of-illness approach. Methods: We analyzed 121 consecutive patients with OPC from the Southern Health Care Region of Sweden. We estimated the direct medical costs and indirect costs (e.g., disease-related morbidity and premature death) from 1 month prior to OPC diagnosis until 3 years after treatment completion. Results: The mean total cost per patient was €103 386 for HPV-positive and €120 244 for HPV-negative OPC. Eighty-one percent of the patients analyzed were HPV-positive: Accordingly, HPV-positive OPC represented 79% of the total cost of OPC. The mean total cost of stage I, II, III, IVA, IVB, and IVC, regardless of HPV status, was €59 424, €57 000, €69 246, €115 770, €234 459, and €21 930, respectively, of which indirect costs were estimated at €22 493 (37.8%), €14 754 (25.9%), €28 681 (41.4%), €67 107 (58%), €166 280 (70.9%), and €0. Tonsillar cancer represented 64% of OPC, with a mean total cost of €117 512 per patient. Conclusion: The societal cost of OPC is substantial. HPV-associated OPC comprises 79% of the total cost of this disease. The data presented in this study may be used in analytical models to aid decision makers in determining the potential value of gender-neutral HPV vaccination.

Suggested Citation

  • Maria Silfverschiöld & Johanna Sjövall & Johan Wennerberg & Ellinor Östensson & Lennart Greiff, 2019. "Societal cost of oropharyngeal cancer by human papillomavirus status, cancer stage, and subsite," PLOS ONE, Public Library of Science, vol. 14(7), pages 1-9, July.
    • Handle: RePEc:plo:pone00:0220534
    DOI: 10.1371/journal.pone.0220534
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    1. Maria Silfverschiöld & Kristin Carlwig & Johan Jarl & Lennart Greiff & Per Nilsson & Johan Wennerberg & Björn Zackrisson & Ellinor Östensson & Johanna Sjövall, 2024. "Cost-effectiveness analysis of (accelerated) pre-operative versus (conventional) post-operative radiotherapy for patients with oral cavity cancer in Sweden," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 25(1), pages 177-185, February.

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