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A modified two-compartment model for measurement of renal function using dynamic contrast-enhanced computed tomography

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  • Kai Jiang
  • Christopher M Ferguson
  • Abdelrhman Abumoawad
  • Ahmed Saad
  • Stephen C Textor
  • Lilach O Lerman

Abstract

Objectives: To validate and adapt a modified two-compartment model, originally developed for magnetic resonance imaging, for measuring human single-kidney glomerular filtration rate (GFR) and perfusion using dynamic contrast-enhanced computed tomography (DCE-CT). Methods: This prospective study was approved by the institutional review board, and written informed consent was obtained from all patients. Thirty-eight patients with essential hypertension (EH, n = 13) or atherosclerotic renal artery stenosis (ARAS, n = 25) underwent renal DCE-CT for GFR and perfusion measurement using a modified two-compartment model. Iothalamate clearance was used to measure reference total GFR, which was apportioned into single-kidney GFR by renal blood flow. Renal perfusion was also calculated using a conventional deconvolution algorithm. Validation of GFR and perfusion and inter-observer reproducibility, were conducted by using the Pearson correlation and Bland-Altman analysis. Results: Both the two-compartment model and iothalamate clearance detected in ARAS patients lower GFR in the stenotic compared to the contralateral and EH kidneys. GFRs measured by DCE-CT and iothalamate clearance showed a close match (r = 0.94, P

Suggested Citation

  • Kai Jiang & Christopher M Ferguson & Abdelrhman Abumoawad & Ahmed Saad & Stephen C Textor & Lilach O Lerman, 2019. "A modified two-compartment model for measurement of renal function using dynamic contrast-enhanced computed tomography," PLOS ONE, Public Library of Science, vol. 14(7), pages 1-18, July.
    • Handle: RePEc:plo:pone00:0219605
    DOI: 10.1371/journal.pone.0219605
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