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Correlates of telomere length shortening in peripheral leukocytes of HIV-infected individuals and association with leukoaraiosis

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  • Rumi Minami
  • Soichiro Takahama
  • Masahiro Yamamoto

Abstract

Telomere length (TL) is a marker of cellular and biological aging. Human immunodeficiency virus (HIV) infection has been reported to be associated with short TLs, which suggests that accelerated biological aging occurs in some cellular compartments of HIV+ individuals. In this study, we measured the TLs of peripheral leukocytes of HIV+ and healthy individuals and examined the biological and environmental correlates of TL. We also investigated the influence of TL on leukoaraiosis, an indicator of cerebral small vessel disease, in HIV+ individuals. Three hundred and twenty-five HIV+ individuals who received stable combination antiretroviral therapy (cART) for >1 year and achieved viral loads of

Suggested Citation

  • Rumi Minami & Soichiro Takahama & Masahiro Yamamoto, 2019. "Correlates of telomere length shortening in peripheral leukocytes of HIV-infected individuals and association with leukoaraiosis," PLOS ONE, Public Library of Science, vol. 14(6), pages 1-11, June.
    • Handle: RePEc:plo:pone00:0218996
    DOI: 10.1371/journal.pone.0218996
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