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Rapid, point-of-care diagnosis of tuberculosis with novel Truenat assay: Cost-effectiveness analysis for India’s public sector

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  • David J Lee
  • Nagalingeswaran Kumarasamy
  • Stephen C Resch
  • Gomathi N Sivaramakrishnan
  • Kenneth H Mayer
  • Srikanth Tripathy
  • A David Paltiel
  • Kenneth A Freedberg
  • Krishna P Reddy

Abstract

Background: Truenat is a novel molecular assay that rapidly detects tuberculosis (TB) and rifampicin-resistance. Due to the portability of its battery-powered testing platform, it may be valuable in peripheral healthcare settings in India. Methods: Using a microsimulation model, we compared four TB diagnostic strategies for HIV-negative adults with presumptive TB: (1) sputum smear microscopy in designated microscopy centers (DMCs) (SSM); (2) Xpert MTB/RIF in DMCs (Xpert); (3) Truenat in DMCs (Truenat DMC); and (4) Truenat for point-of-care testing in primary healthcare facilities (Truenat POC). We projected life expectancy, costs, incremental cost-effectiveness ratios (ICERs), and 5-year budget impact of deploying Truenat POC in India’s public sector. We defined a strategy “cost-effective” if its ICER was

Suggested Citation

  • David J Lee & Nagalingeswaran Kumarasamy & Stephen C Resch & Gomathi N Sivaramakrishnan & Kenneth H Mayer & Srikanth Tripathy & A David Paltiel & Kenneth A Freedberg & Krishna P Reddy, 2019. "Rapid, point-of-care diagnosis of tuberculosis with novel Truenat assay: Cost-effectiveness analysis for India’s public sector," PLOS ONE, Public Library of Science, vol. 14(7), pages 1-17, July.
    • Handle: RePEc:plo:pone00:0218890
    DOI: 10.1371/journal.pone.0218890
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    References listed on IDEAS

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    1. Ramnath Subbaraman & Ruvandhi R Nathavitharana & Srinath Satyanarayana & Madhukar Pai & Beena E Thomas & Vineet K Chadha & Kiran Rade & Soumya Swaminathan & Kenneth H Mayer, 2016. "The Tuberculosis Cascade of Care in India’s Public Sector: A Systematic Review and Meta-analysis," PLOS Medicine, Public Library of Science, vol. 13(10), pages 1-38, October.
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