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Differences in biological behaviors between young and elderly patients with colorectal cancer

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  • Chinock Cheong
  • Seung Yeop Oh
  • Young Bae Kim
  • Kwang Wook Suh

Abstract

Background: We investigated the differences in biological behaviors of sporadic colorectal cancer (CRC) between young and elderly patients. CRC is a common cancer, with a mean age at onset of > 65 years. However, recent reports indicate increasing rates in younger populations. The biological behaviors of sporadic CRC in elderly patients could differ from those in young patients. Methods: Between September 2007 and August 2012, we selected 723 CRC patients from our institution. The patients were divided into Group Y (n = 127, aged ≤50 years) and Group O (n = 596, aged >50 years). The clinicopathologic and oncologic outcomes in the two groups were compared. Results: Group Y tumors were characterized by higher incidences of mucin production (13.4% vs. 6.7%; P = 0.017), high microsatellite instability (MSI-H) (19.8% vs. 5.2%; P

Suggested Citation

  • Chinock Cheong & Seung Yeop Oh & Young Bae Kim & Kwang Wook Suh, 2019. "Differences in biological behaviors between young and elderly patients with colorectal cancer," PLOS ONE, Public Library of Science, vol. 14(6), pages 1-11, June.
    • Handle: RePEc:plo:pone00:0218604
    DOI: 10.1371/journal.pone.0218604
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