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CD4 count recovery and associated factors among individuals enrolled in the South African antiretroviral therapy programme: An analysis of national laboratory based data

Author

Listed:
  • Tendesayi Kufa
  • Zara Shubber
  • William MacLeod
  • Simbarashe Takuva
  • Sergio Carmona
  • Jacob Bor
  • Marelize Gorgens
  • Yogan Pillay
  • Adrian Puren
  • Jeffrey W Eaton
  • Nicole Fraser-Hurt

Abstract

Background: We describe CD4 count recovery among HIV positive individuals who initiated antiretroviral therapy (ART) with and without severe immune suppression using complete laboratory data from South Africa’s national HIV treatment programme between 2010 and 2014 and discuss implications for CD4 count monitoring. Methods: Retrospective analysis of routinely collected laboratory data from South Africa’s National Health Laboratory Service (NHLS). A probabilistic record linkage algorithm was used to create a cohort of HIV positive individuals who initiated ART between 2010 and 2014 based on timing of CD4 count and viral load measurements. A CD4 count 200 cells/μl, >350 cells/μl and >500 cells/μl corresponded with mean follow up durations of 1.5 years (standard deviation [s.d] 1.1), 1.9years (s.d 1.2) and 2.1 years (s.d 1.3 years). For those with CD4 counts

Suggested Citation

  • Tendesayi Kufa & Zara Shubber & William MacLeod & Simbarashe Takuva & Sergio Carmona & Jacob Bor & Marelize Gorgens & Yogan Pillay & Adrian Puren & Jeffrey W Eaton & Nicole Fraser-Hurt, 2019. "CD4 count recovery and associated factors among individuals enrolled in the South African antiretroviral therapy programme: An analysis of national laboratory based data," PLOS ONE, Public Library of Science, vol. 14(5), pages 1-15, May.
    • Handle: RePEc:plo:pone00:0217742
    DOI: 10.1371/journal.pone.0217742
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