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Skin autofluorescence is associated with rapid renal function decline in subjects at increased risk of coronary artery disease

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  • Chun-Cheng Wang
  • Ming-Yi Shen
  • Kuan-Cheng Chang
  • Guei-Jane Wang
  • Shu-Hui Liu
  • Chiz-Tzung Chang

Abstract

Skin autofluorescence (AF) has been validated as a tool for estimating tissue advanced glycation end products (AGEs) accumulation and predicting long-term cardiovascular outcomes. However, whether measurements of skin AF could predict renal function decline remains controversial. From April, 2014 to April, 2015, we enrolled 245 subjects with at least two conventional risk factors for coronary artery disease (CAD). All were measured for body height and weight, blood pressure, plasma creatinine level, and skin AF at the start of the study. Baseline demographics and laboratory tests data were obtained by chart reviews and patient interviews. Serial plasma creatinine levels were followed regularly every 6–12 months for 2 years. In a stepwise multivariate linear regression analysis, skin AF, was an independent factor for predicting the relative renal function decline rate after adjustment of multiple covariates (ß = -0.036±0.016; p = 0.03). Subgroups analysis revealed that skin AF was a significant factor for relative renal function decline rate in subgroups of age

Suggested Citation

  • Chun-Cheng Wang & Ming-Yi Shen & Kuan-Cheng Chang & Guei-Jane Wang & Shu-Hui Liu & Chiz-Tzung Chang, 2019. "Skin autofluorescence is associated with rapid renal function decline in subjects at increased risk of coronary artery disease," PLOS ONE, Public Library of Science, vol. 14(5), pages 1-12, May.
    • Handle: RePEc:plo:pone00:0217203
    DOI: 10.1371/journal.pone.0217203
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