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Improving the measurement of TMS-assessed voluntary activation in the knee extensors

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  • Jeanne Dekerle
  • Aaron Greenhouse-Tucknott
  • James G Wrightson
  • Lisa Schäfer
  • Paul Ansdell

Abstract

Purpose: To test the accuracy, validity, reliability and sensitivity of an alternative method for the measure of TMS-assessed voluntary activation (VATMS) in the knee extensors. Methods: Ten healthy males (24 ± 5 years) completed a neuromuscular assessment protocol before and after a fatiguing isometric exercise: two sets of five contractions (50%, 62.5%, 75%, 87.5%, 100% Maximal Voluntary Contraction; MVC) with superimposed TMS-evoked twitches for calculation of VATMS using either the first 5 stimulations (1x5C) or all 10 (2x5C). This was performed on two separate occasions (between-day reliability). Accuracy and validity were compared with a routinely used protocol [i.e. 50%, 75%, and 100% of MVC (1x3C) performed three times (3x3C)]. Results: 95% confidence interval for estimated resting twitch, a key determinant of VATMS, was similar between 1x5C, 2x5C, and 3x3C but improved by six-fold when compared to 1x3C (P 0.05). Absolute reliability was strong enough for both 1x5C and 2x5C to depict a true detectable change in the sample’s VATMS following the fatiguing exercise (TEM

Suggested Citation

  • Jeanne Dekerle & Aaron Greenhouse-Tucknott & James G Wrightson & Lisa Schäfer & Paul Ansdell, 2019. "Improving the measurement of TMS-assessed voluntary activation in the knee extensors," PLOS ONE, Public Library of Science, vol. 14(6), pages 1-17, June.
    • Handle: RePEc:plo:pone00:0216981
    DOI: 10.1371/journal.pone.0216981
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