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Circulating sphingosine-1-phosphate as a prognostic biomarker for community-acquired pneumonia

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  • Shih-Chang Hsu
  • Jer-Hwa Chang
  • Yuan-Pin Hsu
  • Kuan-Jen Bai
  • Shau-Ku Huang
  • Chin-Wang Hsu

Abstract

Early determination of the severity of Community-Acquired Pneumonia (CAP) is essential for better disease prognosis. Current predictors are suboptimal, and their clinical utility remains to be defined, highlighting the need for developing biomarkers with efficacious prognostic value. Sphingosine-1-phosphate (S1P) is a bioactive sphingolipid with a documented regulatory role in immune defense and maintenance of endothelial barrier integrity. For early diagnose of CAP and recognition of severe CAP patients, we conduct this pilot study to access the potential utility of the circulating S1P in an Emergency department setting. In the prospective study, plasma S1P levels were quantified in healthy controls and patients with CAP. Also, their discriminating power was assessed by receiver operating characteristic analysis. The association between S1P levels and disease severity indices was assessed by Spearman correlation and logistic regression tests. Patients with CAP had significantly higher plasma S1P levels than healthy individuals (CAP: 27.54 ng/ml, IQR = 14.37–49.99 ng/ml; Controls: 10.58 ng/ml, IQR = 4.781–18.91 ng/ml; p

Suggested Citation

  • Shih-Chang Hsu & Jer-Hwa Chang & Yuan-Pin Hsu & Kuan-Jen Bai & Shau-Ku Huang & Chin-Wang Hsu, 2019. "Circulating sphingosine-1-phosphate as a prognostic biomarker for community-acquired pneumonia," PLOS ONE, Public Library of Science, vol. 14(5), pages 1-13, May.
    • Handle: RePEc:plo:pone00:0216963
    DOI: 10.1371/journal.pone.0216963
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    1. Sabine Vettorazzi & Constantin Bode & Lien Dejager & Lucien Frappart & Ekaterina Shelest & Carina Klaßen & Alpaslan Tasdogan & Holger M. Reichardt & Claude Libert & Marion Schneider & Falk Weih & N. H, 2015. "Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1," Nature Communications, Nature, vol. 6(1), pages 1-12, November.
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