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The effect of propranolol on the prognosis of hepatocellular carcinoma: A nationwide population-based study

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  • Ping-Ying Chang
  • Chi-Hsiang Chung
  • Wei-Chou Chang
  • Chun-Shu Lin
  • Hsuan-Hwai Lin
  • Ming-Shen Dai
  • Ching-Liang Ho
  • Wu-Chien Chien

Abstract

Background: Beta-blockers can reduce recurrence, metastasis, and mortality in various cancers. In this study, we investigated the effect of propranolol, a non-selective beta-blocker on overall survival (OS) in unresectable/metastatic hepatocellular carcinoma (HCC) and on recurrence-free survival (RFS) in resectable, curable HCC. Methods: Data were retrieved from the Taiwan National Health Insurance Research Database between January 2000 and December 2013. Propranolol users (for >1 year) and non-propranolol users were matched using a 1:2 propensity score in both cohorts. Results: The unresectable/metastatic HCC cohort comprised 1,560 propranolol users and 3,120 non-propranolol users (control group). On multivariate Cox regression analysis of HCC mortality, propranolol significantly reduced the mortality risk by 22% (hazard ratio [HR] = 0.78, 95% confidence interval [CI] 0.72–0.84, P

Suggested Citation

  • Ping-Ying Chang & Chi-Hsiang Chung & Wei-Chou Chang & Chun-Shu Lin & Hsuan-Hwai Lin & Ming-Shen Dai & Ching-Liang Ho & Wu-Chien Chien, 2019. "The effect of propranolol on the prognosis of hepatocellular carcinoma: A nationwide population-based study," PLOS ONE, Public Library of Science, vol. 14(5), pages 1-14, May.
    • Handle: RePEc:plo:pone00:0216828
    DOI: 10.1371/journal.pone.0216828
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    1. Stefanos Bonovas & Georgios K Nikolopoulos & Pantelis G Bagos, 2012. "Use of Fibrates and Cancer Risk: A Systematic Review and Meta-Analysis of 17 Long-Term Randomized Placebo-Controlled Trials," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-9, September.
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