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Epidemiology and treatment approaches in management of invasive fungal infections in hematological malignancies: Results from a single-centre study

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Listed:
  • Nicola Stefano Fracchiolla
  • Mariarita Sciumè
  • Nicola Orofino
  • Francesca Guidotti
  • Anna Grancini
  • Fabrizio Cavalca
  • Alessandra Freyrie
  • Maria Cecilia Goldaniga
  • Dario Consonni
  • Veronica Mattiello
  • Loredana Pettine
  • Agostino Cortelezzi

Abstract

Invasive fungal infections (IFIs) are a leading cause of morbidity and attributable mortality in oncohematologic patients. Timely diagnosis is essential but challenging. Herein we retrospectively describe 221 cases of antifungal treatments (AFT) administered in a monocentric real-life cohort of hematological malignancies. Between January 2010 and July 2017, 196 oncohematologic patients were treated with AFT at our Hematology Department. Diagnosis of IFIs was carried out according to EORTC/MSG-2008 guidelines.The most represented disease was acute myeloid leukemia (104 patients). Median age was 61 years; at fever onset 177 (80%) patients had a neutrophil count

Suggested Citation

  • Nicola Stefano Fracchiolla & Mariarita Sciumè & Nicola Orofino & Francesca Guidotti & Anna Grancini & Fabrizio Cavalca & Alessandra Freyrie & Maria Cecilia Goldaniga & Dario Consonni & Veronica Mattie, 2019. "Epidemiology and treatment approaches in management of invasive fungal infections in hematological malignancies: Results from a single-centre study," PLOS ONE, Public Library of Science, vol. 14(5), pages 1-14, May.
    • Handle: RePEc:plo:pone00:0216715
    DOI: 10.1371/journal.pone.0216715
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