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Risk factors for incident anemia of chronic diseases: A cohort study

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  • Yun-Gyoo Lee
  • Yoosoo Chang
  • Jihoon Kang
  • Dong-Hoe Koo
  • Seung-Sei Lee
  • Seungho Ryu
  • Sukjoong Oh

Abstract

Objective: Anemia of chronic disease (ACD) refers to hypoproliferative anemia in the context of acute or chronic activation of the immune system. There is a paucity of prospective data addressing the risk factors for ACD development. An association between common chronic diseases and ACD was examined cross-sectionally and longitudinally. Method: A cohort of 265,459 healthy participants without ACD at baseline were prospectively followed annually or biennially. Results: During average follow-up period of 62 months, 4,906 participants developed ACD (incidence rate 3.58 per 1000 person-years). Multivariable-adjusted hazard ratio (HR) [95% confidence interval (CI)] for incident ACD comparing estimated glomerular filtration rate 30–60 and

Suggested Citation

  • Yun-Gyoo Lee & Yoosoo Chang & Jihoon Kang & Dong-Hoe Koo & Seung-Sei Lee & Seungho Ryu & Sukjoong Oh, 2019. "Risk factors for incident anemia of chronic diseases: A cohort study," PLOS ONE, Public Library of Science, vol. 14(5), pages 1-11, May.
    • Handle: RePEc:plo:pone00:0216062
    DOI: 10.1371/journal.pone.0216062
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