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Not all moderate disease is the same – Identification of disability trajectories among patients with rheumatoid arthritis and moderate disease activity

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  • Yi Pan
  • Sam Norton
  • James M Gwinnutt
  • Lianne Kearsley-Fleet
  • Deborah P M Symmons
  • Mark Lunt
  • Adam Young
  • BSRBR-RA Control Centre Consortium
  • Kimme L Hyrich
  • Suzanne M M Verstappen

Abstract

Background: United Kingdom guidelines for the use of biologic disease modifying anti-rheumatic drugs (bDMARDS) for rheumatoid arthritis (RA) require patients to have active disease (Disease Activity Score [DAS28] >5.1) and have failed ≥2 previous conventional synthetic DMARDs (csDMARD). Patients with moderate disease activity (MDA) do not meet these criteria, yet often have poor outcomes. This study aimed to identify trajectory groups of disability scores over three years in RA patients with MDA. Methods: The study included biologic-naïve patients receiving csDMARDs only with MDA (3.2

Suggested Citation

  • Yi Pan & Sam Norton & James M Gwinnutt & Lianne Kearsley-Fleet & Deborah P M Symmons & Mark Lunt & Adam Young & BSRBR-RA Control Centre Consortium & Kimme L Hyrich & Suzanne M M Verstappen, 2019. "Not all moderate disease is the same – Identification of disability trajectories among patients with rheumatoid arthritis and moderate disease activity," PLOS ONE, Public Library of Science, vol. 14(5), pages 1-11, May.
    • Handle: RePEc:plo:pone00:0215999
    DOI: 10.1371/journal.pone.0215999
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