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Quantitative CT analysis of honeycombing area predicts mortality in idiopathic pulmonary fibrosis with definite usual interstitial pneumonia pattern: A retrospective cohort study

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  • Hiroaki Nakagawa
  • Emiko Ogawa
  • Kentaro Fukunaga
  • Daisuke Kinose
  • Masafumi Yamaguchi
  • Taishi Nagao
  • Sachiko Tanaka-Mizuno
  • Yasutaka Nakano

Abstract

Background: Honeycombing on high-resolution computed tomography (HRCT) images is a key finding in idiopathic pulmonary fibrosis (IPF). In IPF, honeycombing area determined by quantitative CT analysis is correlated with pulmonary function test findings. We hypothesized that quantitative CT-derived honeycombing area (HA) might predict mortality in patients with IPF. Materials and methods: Chest HRCT images of 52 IPF patients with definite usual interstitial pneumonia (UIP) pattern were retrospectively evaluated. Mortality data up to July 31, 2016, were recorded. Using a computer-aided system, HA and percentage of HA (%HA) were measured quantitatively. Predictors of 3-year mortality were evaluated using logistic regression models. Results: The median %HA, %predicted forced vital capacity (FVC) and composite physiologic index (CPI) were 3.8%, 83.6%, and 33.6, respectively. According to GAP (gender, age, and physiology) stage, 20, 14, and 5 patients were classified under stages I-II-III, respectively. Percentage of HA was significantly correlated with %FVC, CPI, and GAP stage (all, p

Suggested Citation

  • Hiroaki Nakagawa & Emiko Ogawa & Kentaro Fukunaga & Daisuke Kinose & Masafumi Yamaguchi & Taishi Nagao & Sachiko Tanaka-Mizuno & Yasutaka Nakano, 2019. "Quantitative CT analysis of honeycombing area predicts mortality in idiopathic pulmonary fibrosis with definite usual interstitial pneumonia pattern: A retrospective cohort study," PLOS ONE, Public Library of Science, vol. 14(3), pages 1-11, March.
    • Handle: RePEc:plo:pone00:0214278
    DOI: 10.1371/journal.pone.0214278
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    Cited by:

    1. Lukas Ebner & Stergios Christodoulidis & Thomai Stathopoulou & Thomas Geiser & Odile Stalder & Andreas Limacher & Johannes T Heverhagen & Stavroula G Mougiakakou & Andreas Christe, 2020. "Meta-analysis of the radiological and clinical features of Usual Interstitial Pneumonia (UIP) and Nonspecific Interstitial Pneumonia (NSIP)," PLOS ONE, Public Library of Science, vol. 15(1), pages 1-21, January.

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