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Pretreatment neutrophil-to-lymphocyte ratio predicts clinical relapse of ulcerative colitis after tacrolimus induction

Author

Listed:
  • Yu Nishida
  • Shuhei Hosomi
  • Hirokazu Yamagami
  • Naoko Sugita
  • Shigehiro Itani
  • Tomomi Yukawa
  • Koji Otani
  • Yasuaki Nagami
  • Fumio Tanaka
  • Koichi Taira
  • Noriko Kamata
  • Tetsuya Tanigawa
  • Toshio Watanabe
  • Yasuhiro Fujiwara

Abstract

Objectives: Although tacrolimus is useful as an induction therapy in patients with ulcerative colitis (UC), information regarding the long-term outcome after tacrolimus therapy is insufficient. The aim of this study was to evaluate the clinical significance of the pretreatment neutrophil-to-lymphocyte ratio (NLR) as a prognostic factor in patients with UC receiving tacrolimus, to aid treatment selection. Materials and methods: Patients with moderate-to-severe active UC who received oral tacrolimus induction therapy and subsequent immunomodulatory maintenance therapy at our hospital between 2009 and 2017 and who showed clinical response at week 12, were retrospectively enrolled. Cox regression analysis was conducted to study the prognostic role of the pretreatment NLR. The combined impact of the NLR and other known prognostic factors was investigated with multivariate regression. Results: Among 45 patients included in this study, 21 patients experienced relapse during a median follow-up period of 16.6 months. Multivariate Cox regression analysis identified the pretreatment NLR (hazard ratio [HR]: 0.82, 95% confidence interval [CI]: 0.72–0.94, P

Suggested Citation

  • Yu Nishida & Shuhei Hosomi & Hirokazu Yamagami & Naoko Sugita & Shigehiro Itani & Tomomi Yukawa & Koji Otani & Yasuaki Nagami & Fumio Tanaka & Koichi Taira & Noriko Kamata & Tetsuya Tanigawa & Toshio , 2019. "Pretreatment neutrophil-to-lymphocyte ratio predicts clinical relapse of ulcerative colitis after tacrolimus induction," PLOS ONE, Public Library of Science, vol. 14(3), pages 1-13, March.
    • Handle: RePEc:plo:pone00:0213505
    DOI: 10.1371/journal.pone.0213505
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