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Combining quick sequential organ failure assessment score with heart rate variability may improve predictive ability for mortality in septic patients at the emergency department

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  • Sumanth Madhusudan Prabhakar
  • Takashi Tagami
  • Nan Liu
  • Mas’uud Ibnu Samsudin
  • Janson Cheng Ji Ng
  • Zhi Xiong Koh
  • Marcus Eng Hock Ong

Abstract

Background: Although the quick Sequential Organ Failure Assessment (qSOFA) score was recently introduced to identify patients with suspected infection/sepsis, it has limitations as a predictive tool for adverse outcomes. We hypothesized that combining qSOFA score with heart rate variability (HRV) variables improves predictive ability for mortality in septic patients at the emergency department (ED). Methods: This was a retrospective study using the electronic medical record of a tertiary care hospital in Singapore between September 2014 and February 2017. All patients aged 21 years or older who were suspected with infection/sepsis in the ED and received electrocardiography monitoring with ZOLL X Series Monitor (ZOLL Medical Corporation, Chelmsford, MA) were included. We fitted a logistic regression model to predict the 30-day mortality using one of the HRV variables selected from one of each three domains those previously reported as strong association with mortality (i.e. standard deviation of NN [SDNN], ratio of low frequency to high frequency power [LF/HF], detrended fluctuation analysis α-2 [DFA α-2]) in addition to the qSOFA score. The predictive accuracy was assessed with other scoring systems (i.e. qSOFA alone, National Early Warning Score, and Modified Early Warning Score) using the area under the receiver operating characteristic curve. Results: A total of 343 septic patients were included. Non-survivors were significantly older (survivors vs. non-survivors, 65.7 vs. 72.9, p

Suggested Citation

  • Sumanth Madhusudan Prabhakar & Takashi Tagami & Nan Liu & Mas’uud Ibnu Samsudin & Janson Cheng Ji Ng & Zhi Xiong Koh & Marcus Eng Hock Ong, 2019. "Combining quick sequential organ failure assessment score with heart rate variability may improve predictive ability for mortality in septic patients at the emergency department," PLOS ONE, Public Library of Science, vol. 14(3), pages 1-11, March.
  • Handle: RePEc:plo:pone00:0213445
    DOI: 10.1371/journal.pone.0213445
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    References listed on IDEAS

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    1. Fábio M de Castilho & Antonio Luiz P Ribeiro & José Luiz P da Silva & Vandack Nobre & Marcos R de Sousa, 2017. "Heart rate variability as predictor of mortality in sepsis: A prospective cohort study," PLOS ONE, Public Library of Science, vol. 12(6), pages 1-15, June.
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    Cited by:

    1. Jeremy Zhenwen Pong & Stephanie Fook-Chong & Zhi Xiong Koh & Mas’uud Ibnu Samsudin & Takashi Tagami & Calvin J. Chiew & Ting Hway Wong & Andrew Fu Wah Ho & Marcus Eng Hock Ong & Nan Liu, 2019. "Combining Heart Rate Variability with Disease Severity Score Variables for Mortality Risk Stratification in Septic Patients Presenting at the Emergency Department," IJERPH, MDPI, vol. 16(10), pages 1-14, May.

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