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Pancreatic 18F-FDG uptake is increased in type 2 diabetes patients compared to non-diabetic controls

Author

Listed:
  • Guido J Bakker
  • Manon C Vanbellinghen
  • Torsten P Scheithauer
  • C Bruce Verchere
  • Erik S Stroes
  • Nyanza K L M Timmers
  • Hilde Herrema
  • Max Nieuwdorp
  • Hein J Verberne
  • Daniël H van Raalte

Abstract

Introduction: Increasing evidence indicates that the development of type 2 diabetes is driven by chronic low grade beta-cell inflammation. However, it is unclear whether pancreatic inflammation can be noninvasively visualized in type 2 diabetes patients. We aimed to assess pancreatic 18F-FDG uptake in type 2 diabetes patients and controls using 18F-fluorodeoxylglucose positron emission tomography/computed tomography (18F-FDG PET/CT). Material and methods: In this retrospective cross-sectional study, we enrolled 20 type 2 diabetes patients and 65 controls who had undergone a diagnostic 18F-FDG PET/CT scan and obtained standardized uptake values (SUVs) of pancreas and muscle. Pancreatic SUV was adjusted for background uptake in muscle and for fasting blood glucose concentrations. Results: The maximum pancreatic SUVs adjusted for background muscle uptake (SUVmax.m) and fasting blood glucose concentration (SUVglucose) were significantly higher in diabetes patients compared to controls (median 2.86 [IQR 2.24–4.36] compared to 2.15 [IQR 1.51–2.83], p = 0.006 and median 2.76 [IQR 1.18–4.34] compared to 1.91 [IQR 1.27–2.55], p

Suggested Citation

  • Guido J Bakker & Manon C Vanbellinghen & Torsten P Scheithauer & C Bruce Verchere & Erik S Stroes & Nyanza K L M Timmers & Hilde Herrema & Max Nieuwdorp & Hein J Verberne & Daniël H van Raalte, 2019. "Pancreatic 18F-FDG uptake is increased in type 2 diabetes patients compared to non-diabetic controls," PLOS ONE, Public Library of Science, vol. 14(3), pages 1-9, March.
    • Handle: RePEc:plo:pone00:0213202
    DOI: 10.1371/journal.pone.0213202
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