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HBV preS deletion mapping using deep sequencing demonstrates a unique association with viral markers

Author

Listed:
  • Yuichiro Suzuki
  • Shinya Maekawa
  • Nobutoshi Komatsu
  • Mitsuaki Sato
  • Akihisa Tatsumi
  • Mika Miura
  • Shuya Matsuda
  • Masaru Muraoka
  • Natsuko Nakakuki
  • Fumitake Amemiya
  • Shinichi Takano
  • Mitsuharu Fukasawa
  • Yasuhiro Nakayama
  • Tatsuya Yamaguchi
  • Taisuke Inoue
  • Tadashi Sato
  • Minoru Sakamoto
  • Atsuya Yamashita
  • Kohji Moriishi
  • Nobuyuki Enomoto

Abstract

Aim: Deletions are observed frequently in the preS1/S2 region of hepatitis B virus (HBV) genome, in association with liver disease advancement. However, the most significant preS1/S2 region and its influences on viral markers are unclear. Methods: The preS1/S2 HBV regions of 90 patients without antiviral therapy were subjected to deep sequencing and deleted regions influencing viral markers were investigated. Results: From the deletion frequency analysis in each patient, deletions were observed most frequently in the preS2 codon 132–141 region. When the patients were divided into three groups (0–0.1%: n = 27, 0.1%-10%: n = 34, 10–100%: n = 29), based on the deletion frequency, FIB-4 (p

Suggested Citation

  • Yuichiro Suzuki & Shinya Maekawa & Nobutoshi Komatsu & Mitsuaki Sato & Akihisa Tatsumi & Mika Miura & Shuya Matsuda & Masaru Muraoka & Natsuko Nakakuki & Fumitake Amemiya & Shinichi Takano & Mitsuharu, 2019. "HBV preS deletion mapping using deep sequencing demonstrates a unique association with viral markers," PLOS ONE, Public Library of Science, vol. 14(2), pages 1-14, February.
    • Handle: RePEc:plo:pone00:0212559
    DOI: 10.1371/journal.pone.0212559
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    References listed on IDEAS

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    1. Xin Bai & Jian-an Jia & Meng Fang & Shipeng Chen & Xiaotao Liang & Shanfeng Zhu & Shuqin Zhang & Jianfeng Feng & Fengzhu Sun & Chunfang Gao, 2018. "Deep sequencing of HBV pre-S region reveals high heterogeneity of HBV genotypes and associations of word pattern frequencies with HCC," PLOS Genetics, Public Library of Science, vol. 14(2), pages 1-20, February.
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