IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0212354.html
   My bibliography  Save this article

Rivaroxaban administration after acute ischemic stroke: The RELAXED study

Author

Listed:
  • Masahiro Yasaka
  • Kazuo Minematsu
  • Kazunori Toyoda
  • Etsuro Mori
  • Teruyuki Hirano
  • Toshimitsu Hamasaki
  • Hiroshi Yamagami
  • Takehiko Nagao
  • Shinichi Yoshimura
  • Shinichiro Uchiyama
  • for the RELAXED study group

Abstract

The efficacy of early anticoagulation in acute stroke with nonvalvular atrial fibrillation (NVAF) remains unclear. We performed a study to evaluate the risk of recurrent ischemic stroke (IS) and major bleeding in acute IS patients with NVAF who started rivaroxaban. This observational study evaluated patients with NVAF and acute IS/transient ischemic attack (TIA) in the middle cerebral arterial territory who started rivaroxaban within 30 days after the index IS/TIA. The primary endpoints were recurrent IS and major bleeding within 90 days after the index IS/TIA. The relationship between the endpoints and the time to start rivaroxaban was evaluated by correlation analysis using cerebral infarct volume, determined by diffusion-weighted magnetic resonance images within 48 hours of onset of the index IS/TIA. Of 1309 patients analyzed, recurrent IS occurred in 30 (2.3%) and major bleeding in 11 (0.8%) patients. Among patients with known infarct size (N = 1207), those with small (

Suggested Citation

  • Masahiro Yasaka & Kazuo Minematsu & Kazunori Toyoda & Etsuro Mori & Teruyuki Hirano & Toshimitsu Hamasaki & Hiroshi Yamagami & Takehiko Nagao & Shinichi Yoshimura & Shinichiro Uchiyama & for the RELAX, 2019. "Rivaroxaban administration after acute ischemic stroke: The RELAXED study," PLOS ONE, Public Library of Science, vol. 14(2), pages 1-18, February.
    • Handle: RePEc:plo:pone00:0212354
    DOI: 10.1371/journal.pone.0212354
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212354
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0212354&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0212354?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0212354. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.