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Estimation of intravoxel incoherent motion parameters using low b-values

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Listed:
  • Chen Ye
  • Daoyun Xu
  • Yongbin Qin
  • Lihui Wang
  • Rongpin Wang
  • Wuchao Li
  • Zixiang Kuai
  • Yuemin Zhu

Abstract

Intravoxel incoherent motion (IVIM) imaging is a magnetic resonance imaging (MRI) technique widely used in clinical applications for various organs. However, IVIM imaging at low b-values is a persistent problem. This paper aims to investigate in a systematic and detailed manner how the number of low b-values influences the estimation of IVIM parameters. To this end, diffusion-weighted (DW) data with different low b-values were simulated to get insight into the distributions of subsequent IVIM parameters. Then, in vivo DW data with different numbers of low b-values and different number of excitations (NEX) were acquired. Finally, least-squares (LSQ) and Bayesian shrinkage prior (BSP) fitting methods were implemented to estimate IVIM parameters. The influence of the number of low b-values on IVIM parameters was analyzed in terms of relative error (RE) and structural similarity (SSIM). The results showed that the influence of the number of low b-values on IVIM parameters is variable. LSQ is more dependent on the number of low b-values than BSP, but the latter is more sensitive to noise.

Suggested Citation

  • Chen Ye & Daoyun Xu & Yongbin Qin & Lihui Wang & Rongpin Wang & Wuchao Li & Zixiang Kuai & Yuemin Zhu, 2019. "Estimation of intravoxel incoherent motion parameters using low b-values," PLOS ONE, Public Library of Science, vol. 14(2), pages 1-16, February.
    • Handle: RePEc:plo:pone00:0211911
    DOI: 10.1371/journal.pone.0211911
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