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Correlation between macrophage migration inhibitory factor and autophagy in Helicobacter pylori-associated gastric carcinogenesis

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  • Kichul Yoon
  • Nayoung Kim
  • Youngmi Park
  • Bo Kyung Kim
  • Ji Hyun Park
  • Cheol Min Shin
  • Dong Ho Lee
  • Young-Joon Surh

Abstract

The role of macrophage migration inhibitory factor (MIF) and autophagy in gastric cancer is not clear. We determined H. pylori infection status of the subjects and investigated the expression of MIF and autophagy markers (Atg5, LC3A and LC3B) in human gastric tissue at baseline. Then H. pylori eradication was done for H. pylori positive patients and MIF and Atg5 levels were investigated on each follow-up for both H. pylori-eradicated and H. pylori negative patients. Baseline tissue mRNA expression of MIF, Atg5, LC3A and LC3B was measured by real-time PCR in 453 patients (control 165, gastric dysplasia 82, and gastric cancer 206). Three hundred three patients (66.9%) had H. pylori infection at the time of enrollment. Only within H. pylori-positive group, MIF level was significantly elevated in patients with cancer than in control or dysplasia groups (P

Suggested Citation

  • Kichul Yoon & Nayoung Kim & Youngmi Park & Bo Kyung Kim & Ji Hyun Park & Cheol Min Shin & Dong Ho Lee & Young-Joon Surh, 2019. "Correlation between macrophage migration inhibitory factor and autophagy in Helicobacter pylori-associated gastric carcinogenesis," PLOS ONE, Public Library of Science, vol. 14(2), pages 1-15, February.
    • Handle: RePEc:plo:pone00:0211736
    DOI: 10.1371/journal.pone.0211736
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