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Prognostic role of early D-dimer level in patients with acute ischemic stroke

Author

Listed:
  • Jing Zhang
  • Lin Liu
  • Jie Tao
  • Yanlin Song
  • Yimeng Fan
  • Maling Gou
  • Jianguo Xu

Abstract

Object: The purpose of our study was to assess the prognostic role of early D-dimer level in patients with acute ischemic stroke (AIS). Methods: The included patients’ D-dimer levels have to be tested within 24 hours from stroke onset. Poor functional outcome was defined as modified Rankin Scale (mRS) ≥3. The endpoints included recurrence on 5-day diffusion-weighted imaging, 30-day mRS ≥3, 30-day mortality and 90-day mRS ≥3. Regarding to each endpoint, odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the prognostic role of D-dimer in patients with AIS. Results: A total of 2,479 patients were included. The results showed that elevated D-dimer levels were associated with recurrence on 5-day diffusion-weighted imaging (OR = 2.28, 95% CI = 1.32–3.95), 30-day mRS≥3 (OR = 1.59, 95% CI = 1.37–1.85), 30-day mortality (OR = 1.92, 95% CI = 1.27–2.90) and 90-day mRS≥3 (OR = 1.61, 95% CI = 1.05–2.46). Conclusions: In conclusion, for patients with AIS, higher D-dimer level within 24 hours from stroke onset was associated with recurrence on 5-day diffusion-weighted imaging, mortality at 30 days, and poor functional outcome at both 30 days and 90 days. However, more studies are warranted to clarify this issue.

Suggested Citation

  • Jing Zhang & Lin Liu & Jie Tao & Yanlin Song & Yimeng Fan & Maling Gou & Jianguo Xu, 2019. "Prognostic role of early D-dimer level in patients with acute ischemic stroke," PLOS ONE, Public Library of Science, vol. 14(2), pages 1-10, February.
    • Handle: RePEc:plo:pone00:0211458
    DOI: 10.1371/journal.pone.0211458
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