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A retrospective claims analysis: Compliance and discontinuation rates among Canadian patients with multiple sclerosis treated with disease-modifying therapies

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  • Pierre Duquette
  • Michael Yeung
  • Soukaïna Mouallif
  • Hamid Reza Nakhaipour
  • Paola Haddad
  • Robyn Schecter

Abstract

Background: Compliance to disease modifying therapy (DMT) is associated with a reduced risk of relapse, lower healthcare resource utilization, and improved health-related quality of life in patients with multiple sclerosis (MS). Our objective was to assess the compliance and discontinuation rates of fingolimod relative to other oral, injectable, and infusible DMTs available on the market at the time of the study in Canada in patients with relapsing—remitting MS (RRMS). Methods and findings: We conducted a retrospective claims analysis. Patients with RRMS with ≥ 1 prescription for each DMT were included. Compliance (medication possession ratio of ≥ 80%) and discontinuation (gap > 30 days from the end of the index prescription) were calculated at the 6-, 12- and 24-month time points. Compliance with fingolimod at the 6-, 12- and 24-month time points was 75%, 75% and 70%, respectively; compared with DMF [70% (P

Suggested Citation

  • Pierre Duquette & Michael Yeung & Soukaïna Mouallif & Hamid Reza Nakhaipour & Paola Haddad & Robyn Schecter, 2019. "A retrospective claims analysis: Compliance and discontinuation rates among Canadian patients with multiple sclerosis treated with disease-modifying therapies," PLOS ONE, Public Library of Science, vol. 14(1), pages 1-9, January.
    • Handle: RePEc:plo:pone00:0210417
    DOI: 10.1371/journal.pone.0210417
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