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Arterial carboxyhaemoglobin levels in children admitted to PICU: A retrospective observational study

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  • Ankur Chawla
  • Samiran Ray
  • Adela Matettore
  • Mark J Peters

Abstract

While carbon monoxide (CO) is considered toxic, low levels of endogenously produced CO are protective against cellular injury induced by oxidative stress. Carboxyhaemoglobin (COHb) levels have been associated with outcomes in critically ill adults. We aimed to describe the distribution of carboxyhaemoglobin in critically ill children and the relationship of these levels with clinical outcomes. This retrospective observational study was conducted at a large tertiary paediatric intensive care unit (PICU). We included all children admitted to the PICU over a two-year period who underwent arterial blood gas analysis. We measured the following: (i) Population and age-related differences in COHb distribution; (ii) Change in COHb over the first week of admission using a multi-level linear regression analysis; (iii) Uni- and multivariable relationships between COHb and length of ventilation and PICU survival. Arterial COHb levels were available for 559/2029 admissions. The median COHb level was 1.20% (IQR 1.00–1.60%). Younger children had significantly higher COHb levels (p-value

Suggested Citation

  • Ankur Chawla & Samiran Ray & Adela Matettore & Mark J Peters, 2019. "Arterial carboxyhaemoglobin levels in children admitted to PICU: A retrospective observational study," PLOS ONE, Public Library of Science, vol. 14(3), pages 1-10, March.
    • Handle: RePEc:plo:pone00:0209452
    DOI: 10.1371/journal.pone.0209452
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