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Methylated promoter DNA of CDO1 gene and preoperative serum CA19-9 are prognostic biomarkers in primary extrahepatic cholangiocarcinoma

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Listed:
  • Shuji Nakamoto
  • Yusuke Kumamoto
  • Kazuharu Igarashi
  • Yoshiki Fujiyama
  • Nobuyuki Nishizawa
  • Shigenori Ei
  • Hiroshi Tajima
  • Takashi Kaizu
  • Masahiko Watanabe
  • Keishi Yamashita

Abstract

Background: Promoter DNA methylation of Cysteine dioxygenase type1 (CDO1) gene has been clarified as a molecular diagnostic and prognostic indicator in various human cancers. The aim of this study is to investigate the clinical relevance of CDO1 methylation in primary biliary tract cancer (BTC). Methods: CDO1 DNA methylation was assessed by quantitative methylation-specific PCR in 108 BTC tumor tissues and 101 corresponding normal tissues. BTC was composed of extrahepatic cholangiocarcinoma (EHCC) (n = 81) and ampullary carcinoma (AC) (n = 27). Results: The CDO1 methylation value in the tumor tissues was significantly higher than that in the corresponding normal tissues (p

Suggested Citation

  • Shuji Nakamoto & Yusuke Kumamoto & Kazuharu Igarashi & Yoshiki Fujiyama & Nobuyuki Nishizawa & Shigenori Ei & Hiroshi Tajima & Takashi Kaizu & Masahiko Watanabe & Keishi Yamashita, 2018. "Methylated promoter DNA of CDO1 gene and preoperative serum CA19-9 are prognostic biomarkers in primary extrahepatic cholangiocarcinoma," PLOS ONE, Public Library of Science, vol. 13(10), pages 1-14, October.
    • Handle: RePEc:plo:pone00:0205864
    DOI: 10.1371/journal.pone.0205864
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