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Prevalence of hypothyroidism in patients with hyponatremia: A retrospective cross-sectional study

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  • Takanobu Nagata
  • Shoko Nakajima
  • Atsushi Fujiya
  • Hiroshi Sobajima
  • Makoto Yamaguchi

Abstract

Objective: Hypothyroidism has been suggested to be an uncommon cause of hyponatremia. However, little is known about the prevalence of hypothyroidism in patients with different levels of hyponatremia. The objective of this study was to investigate the prevalence of hypothyroidism among patients with hyponatremia of varying severity while taking into consideration potential confounders associated with thyroid function. Methods: All data on thyrotropin (TSH), free thyroxine (T4), and serum sodium (Na) levels were retrospectively collected from medical records at two Japanese tertiary hospitals. The main outcome measure was overt hypothyroidism, defined as TSH > 10.0 μIU/mL and free T4

Suggested Citation

  • Takanobu Nagata & Shoko Nakajima & Atsushi Fujiya & Hiroshi Sobajima & Makoto Yamaguchi, 2018. "Prevalence of hypothyroidism in patients with hyponatremia: A retrospective cross-sectional study," PLOS ONE, Public Library of Science, vol. 13(10), pages 1-8, October.
  • Handle: RePEc:plo:pone00:0205687
    DOI: 10.1371/journal.pone.0205687
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