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Incidence rates of dysvascular lower extremity amputation changes in Northern Netherlands: A comparison of three cohorts of 1991-1992, 2003-2004 and 2012-2013

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  • Behrouz Fard
  • Pieter U Dijkstra
  • Roy E Stewart
  • Jan H B Geertzen

Abstract

Objective: To analyze the incidence rates of dysvascular major lower extremity amputations (LEA) in Northern Netherlands in 2012–2013 compared to previous cohorts in 1991–1992 and 2003–2004. Design: Retrospective cohort study. Participants: Adults (N = 343) with first ever dysvascular LEA at ankle disarticulation or more proximal levels. The median age (interquartile range) was 74.2 years (64.5–81.9), 64% were male and 55% had been diagnosed with diabetes mellitus (DM). Main outcome measures: Crude and age-standardized incidence rates of major LEA per 100.000 person-years. Results: Crude incidence rate (IR) of first ever major LEA in 2012–2013 was 9.9 per 100.000 person-years, while the age-standardized IR was 7.7 per 100.000 person-years. A Poisson regression analysis showed that amputation rates among men were 2.3 times higher compared to women (95%CI 1.9–2.6), while in 2012–2013 the population aged >63 years had decreased amputation rates compared to 1991–1992. In the DM population the crude IR decreased from 142.6 per 100.000 person-years in 2003–2004 to 89.2 per 100.000 person-years in 2012–2013 (p

Suggested Citation

  • Behrouz Fard & Pieter U Dijkstra & Roy E Stewart & Jan H B Geertzen, 2018. "Incidence rates of dysvascular lower extremity amputation changes in Northern Netherlands: A comparison of three cohorts of 1991-1992, 2003-2004 and 2012-2013," PLOS ONE, Public Library of Science, vol. 13(9), pages 1-12, September.
    • Handle: RePEc:plo:pone00:0204623
    DOI: 10.1371/journal.pone.0204623
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