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Realtime phase-amplitude coupling analysis of micro electrode recorded brain signals

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  • David Chao-Chia Lu
  • Chadwick Boulay
  • Adrian D C Chan
  • Adam J Sachs

Abstract

Objective: To demonstrate a method to calculate phase amplitude coupling (PAC) quickly and robustly for realtime applications. Methods: We designed and implemented a multirate PAC algorithm with efficient filter bank processing and efficient computation of PAC for many frequency-pair combinations. We tested the developed algorithm for computing PAC on simulated data and on intraoperative neural recording data obtained during deep brain stimulation (DBS) electrode implantation surgery. Results: A combination of parallelized frequency-domain filtering and modulation index for PAC estimation provided robust results that could be calculated in real time on modest computing hardware. Conclusion: The standard methods for calculating PAC can be optimized for quick and robust performance. Significance: These results demonstrated that PAC can be extracted in real time and is suitable for neurofeedback applications.

Suggested Citation

  • David Chao-Chia Lu & Chadwick Boulay & Adrian D C Chan & Adam J Sachs, 2018. "Realtime phase-amplitude coupling analysis of micro electrode recorded brain signals," PLOS ONE, Public Library of Science, vol. 13(9), pages 1-16, September.
    • Handle: RePEc:plo:pone00:0204260
    DOI: 10.1371/journal.pone.0204260
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