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Prevalence and trends of polypharmacy among HIV-positive and -negative men in the Multicenter AIDS Cohort Study from 2004 to 2016

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  • Deanna Ware
  • Frank J Palella Jr.
  • Kara W Chew
  • M Reuel Friedman
  • Gypsyamber D’Souza
  • Ken Ho
  • Michael Plankey

Abstract

Rates of aging-related comorbidities, which require targeted medications to treat, have been shown to be increased among persons living with HIV compared with uninfected counterparts. Polypharmacy is generally defined as the concurrent use of 5 or more medications. We investigated polypharmacy prevalence for non-HIV medications over a 12-year period among HIV-positive and -negative participants in the Multicenter AIDS Cohort Study. Information regarding non-HIV medication use, HIV status, age, race/ethnicity, enrollment period, and medication insurance was obtained on 3,160 participants from semiannual visits between 2004 and 2016. Polypharmacy was defined as taking 5 or more non-HIV medications since the last health care visit. Generalized estimating equation models with repeated measures were produced overall and by HIV status to examine polypharmacy. The unadjusted prevalence of polypharmacy across all study visits was 18.6% and was higher among HIV-positive participants (24.4%) compared with HIV-negative participants (11.6%) (P

Suggested Citation

  • Deanna Ware & Frank J Palella Jr. & Kara W Chew & M Reuel Friedman & Gypsyamber D’Souza & Ken Ho & Michael Plankey, 2018. "Prevalence and trends of polypharmacy among HIV-positive and -negative men in the Multicenter AIDS Cohort Study from 2004 to 2016," PLOS ONE, Public Library of Science, vol. 13(9), pages 1-14, September.
    • Handle: RePEc:plo:pone00:0203890
    DOI: 10.1371/journal.pone.0203890
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