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Colorectal cancer molecular classification using BRAF, KRAS, microsatellite instability and CIMP status: Prognostic implications and response to chemotherapy

Author

Listed:
  • Oscar Murcia
  • Míriam Juárez
  • María Rodríguez-Soler
  • Eva Hernández-Illán
  • Mar Giner-Calabuig
  • Miren Alustiza
  • Cecilia Egoavil
  • Adela Castillejo
  • Cristina Alenda
  • Víctor Barberá
  • Carolina Mangas-Sanjuan
  • Ana Yuste
  • Luís Bujanda
  • Joan Clofent
  • Montserrat Andreu
  • Antoni Castells
  • Xavier Llor
  • Pedro Zapater
  • Rodrigo Jover

Abstract

Objective: The aim of this study was to validate a molecular classification of colorectal cancer (CRC) based on microsatellite instability (MSI), CpG island methylator phenotype (CIMP) status, BRAF, and KRAS and investigate each subtype’s response to chemotherapy. Design: This retrospective observational study included a population-based cohort of 878 CRC patients. We classified tumours into five different subtypes based on BRAF and KRAS mutation, CIMP status, and MSI. Patients with advanced stage II (T4N0M0) and stage III tumours received 5-fluoruracil (5-FU)-based chemotherapy or no adjuvant treatment based on clinical criteria. The main outcome was disease-free survival (DFS). Results: Patients with the combination of microsatellite stable (MSS) tumours, BRAF mutation and CIMP positive exhibited the worst prognosis in univariate (log rank P

Suggested Citation

  • Oscar Murcia & Míriam Juárez & María Rodríguez-Soler & Eva Hernández-Illán & Mar Giner-Calabuig & Miren Alustiza & Cecilia Egoavil & Adela Castillejo & Cristina Alenda & Víctor Barberá & Carolina Mang, 2018. "Colorectal cancer molecular classification using BRAF, KRAS, microsatellite instability and CIMP status: Prognostic implications and response to chemotherapy," PLOS ONE, Public Library of Science, vol. 13(9), pages 1-13, September.
    • Handle: RePEc:plo:pone00:0203051
    DOI: 10.1371/journal.pone.0203051
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