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Relationships between histogram analysis of ADC values and complex 18F-FDG-PET parameters in head and neck squamous cell carcinoma

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  • Hans-Jonas Meyer
  • Sandra Purz
  • Osama Sabri
  • Alexey Surov

Abstract

Purpose: Histogram analysis is an emergent imaging technique to further analyze radiological images and to obtain imaging biomarker. In head and neck cancer, MRI and PET are routinely used in clinical practice. The aim of this study was to analyze associations between histogram based ADC parameters and complex FDG-PET derived parameters in head and neck squamous cell carcinoma (HNSCC). Methods: 34 patients (26% female, mean age, 56.7 ± 10.2 years) with primary HNSCC were prospectively included into the study. ADC histogram parameters were calculated by inhouse made matlab software using a whole lesion measurement. For each tumor, maximum and mean standardized uptake values (SUVmax, SUVmean), Total Lesion Glycolysis (TLG) and Metabolic Tumor Volume (MTV) were determined on PET-images. Spearman's correlation coefficient (ρ) was used to analyze associations between investigated parameters. Benjamini-Hochberg correction was used to adjust for multiple testing. Mann-Whitney test was used for group discrimination. P-values

Suggested Citation

  • Hans-Jonas Meyer & Sandra Purz & Osama Sabri & Alexey Surov, 2018. "Relationships between histogram analysis of ADC values and complex 18F-FDG-PET parameters in head and neck squamous cell carcinoma," PLOS ONE, Public Library of Science, vol. 13(9), pages 1-11, September.
    • Handle: RePEc:plo:pone00:0202897
    DOI: 10.1371/journal.pone.0202897
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