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Increased final adult height by gonadotropin-releasing hormone agonist in girls with idiopathic central precocious puberty

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  • Hae Sang Lee
  • Jong Seo Yoon
  • Kyu Jung Park
  • Jin Soon Hwang

Abstract

Objective: Gonadotropin-releasing hormone agonists (GnRHa) are the treatment of choice for central precocious puberty (CPP) and have been widely used for several decades. We determined the effect of GnRHa treatment on the auxological outcomes of girls with idiopathic CPP. Methods: This study included 84 girls treated monthly with depot leuprolide acetate who had reached adult height. We compared their final adult height (FAH) with their initial predicted adult height (PAH). We performed a multivariate analysis of the factors associated with FAH on all girls diagnosed with CPP. Results: We performed the final evaluations at a mean age of 14.1 ± 0.8 years after a mean treatment duration of 2.98 ± 0.73 years (ranging from 1.5–4.8 years). Menarche had occurred at 12.6 ± 0.6 years of age, which was 16.5 ± 6.1 months after discontinuation of GnRHa therapy. Mean FAH was 160.1 ± 5.0 cm, which was significantly higher than the initial PAH (156.1 ± 5.7 cm; P

Suggested Citation

  • Hae Sang Lee & Jong Seo Yoon & Kyu Jung Park & Jin Soon Hwang, 2018. "Increased final adult height by gonadotropin-releasing hormone agonist in girls with idiopathic central precocious puberty," PLOS ONE, Public Library of Science, vol. 13(8), pages 1-8, August.
    • Handle: RePEc:plo:pone00:0201906
    DOI: 10.1371/journal.pone.0201906
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