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Simulating optical coherence tomography for observing nerve activity: A finite difference time domain bi-dimensional model

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  • Francesca Troiani
  • Konstantin Nikolic
  • Timothy G Constandinou

Abstract

We present a finite difference time domain (FDTD) model for computation of A line scans in time domain optical coherence tomography (OCT). The OCT output signal is created using two different simulations for the reference and sample arms, with a successive computation of the interference signal with external software. In this paper we present the model applied to two different samples: a glass rod filled with water-sucrose solution at different concentrations and a peripheral nerve. This work aims to understand to what extent time domain OCT can be used for non-invasive, direct optical monitoring of peripheral nerve activity.

Suggested Citation

  • Francesca Troiani & Konstantin Nikolic & Timothy G Constandinou, 2018. "Simulating optical coherence tomography for observing nerve activity: A finite difference time domain bi-dimensional model," PLOS ONE, Public Library of Science, vol. 13(7), pages 1-14, July.
    • Handle: RePEc:plo:pone00:0200392
    DOI: 10.1371/journal.pone.0200392
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