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Do outpatient statins and ACEIs/ARBs have synergistic effects in reducing the risk of pneumonia? A population-based case-control study

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  • Jiunn-Horng Kang
  • Li-Ting Kao
  • Herng-Ching Lin
  • Ta-Jung Wang
  • Tsung-Yeh Yang

Abstract

Whether statins and an angiotensin-converting enzyme inhibitors (ACEIs) / angiotensin receptor blockors (ARBs) are associated with reduced risks of infection events is still inconclusive. This study aimed to explore the risk of hospitalization for pneumonia among patients who had received treatment with ACEIs/ARBs and/or statins using a population-based dataset. This study included 19,281 patients as cases who were hospitalized for pneumonia and 19,281 controls. We used a logistic regression to compute the odds ratio (OR) and 95% confidence interval (CI) for having previously used statins or an ACEI/ ARB between patients who were hospitalized for pneumonia treatment and controls. We found there were significant associations between hospitalization for pneumonia and statin-only users (p

Suggested Citation

  • Jiunn-Horng Kang & Li-Ting Kao & Herng-Ching Lin & Ta-Jung Wang & Tsung-Yeh Yang, 2018. "Do outpatient statins and ACEIs/ARBs have synergistic effects in reducing the risk of pneumonia? A population-based case-control study," PLOS ONE, Public Library of Science, vol. 13(6), pages 1-10, June.
    • Handle: RePEc:plo:pone00:0199981
    DOI: 10.1371/journal.pone.0199981
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