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Clinical significance of myeloperoxidase-anti-neutrophil cytoplasmic antibody in idiopathic interstitial pneumonias

Author

Listed:
  • Hironao Hozumi
  • Yoshiyuki Oyama
  • Hideki Yasui
  • Yuzo Suzuki
  • Masato Kono
  • Masato Karayama
  • Kazuki Furuhashi
  • Noriyuki Enomoto
  • Tomoyuki Fujisawa
  • Naoki Inui
  • Yutaro Nakamura
  • Takafumi Suda

Abstract

Objective: Although a possible association among myeloperoxidase-anti-neutrophil cytoplasmic antibody (MPO-ANCA), microscopic polyangiitis (MPA), and idiopathic pulmonary fibrosis (IPF) has been suggested, the clinical significance of MPO-ANCA in idiopathic interstitial pneumonias (IIPs), including IPF and non-IPF, remains unclear. We aimed to investigate the frequency of MPO-ANCA positivity, as well as MPA incidence and risk factors for development in patients initially diagnosed with IIP. Methods: We retrospectively analysed 305 consecutive patients who were initially diagnosed as IIP and had MPO-ANCA results available. Results: Of the 305 patients, 26 (8.5%) were MPO-ANCA-positive. Baseline characteristics were similar between the MPO-ANCA-positive and -negative patients. The cumulative 5-year MPA incidence was 24.3% in the MPO-ANCA-positive patients and 0% in the -negative patients (P

Suggested Citation

  • Hironao Hozumi & Yoshiyuki Oyama & Hideki Yasui & Yuzo Suzuki & Masato Kono & Masato Karayama & Kazuki Furuhashi & Noriyuki Enomoto & Tomoyuki Fujisawa & Naoki Inui & Yutaro Nakamura & Takafumi Suda, 2018. "Clinical significance of myeloperoxidase-anti-neutrophil cytoplasmic antibody in idiopathic interstitial pneumonias," PLOS ONE, Public Library of Science, vol. 13(6), pages 1-14, June.
    • Handle: RePEc:plo:pone00:0199659
    DOI: 10.1371/journal.pone.0199659
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