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Is body mass index associated with outcomes of mechanically ventilated adult patients in intensive critical units? A systematic review and meta-analysis

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  • Yonghua Zhao
  • Zhiqiang Li
  • Tao Yang
  • Meiping Wang
  • Xiuming Xi

Abstract

Background: Obesity paradox refers to lower mortality in subjects with higher body mass index (BMI), and has been documented under a variety of condition. However, whether obesity paradox exists in adults requiring mechanical ventilation in intensive critical units (ICU) remains controversial. Methods: MEDLINE, EMBASE, China Biology Medicine disc (CBM) and CINAHL electronic databases were searched from the earliest available date to July 2017, using the following search terms: “body weight”, “body mass index”, “overweight” or “obesity” and “ventilator”, “mechanically ventilated”, “mechanical ventilation”, without language restriction. Subjects were divided into the following categories based on BMI (kg/m2): underweight, 40 kg/m2. The primary outcome was mortality, and included ICU mortality, hospital mortality, short-term mortality (

Suggested Citation

  • Yonghua Zhao & Zhiqiang Li & Tao Yang & Meiping Wang & Xiuming Xi, 2018. "Is body mass index associated with outcomes of mechanically ventilated adult patients in intensive critical units? A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 13(6), pages 1-15, June.
  • Handle: RePEc:plo:pone00:0198669
    DOI: 10.1371/journal.pone.0198669
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