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Statins increase the risk of herpes zoster: A propensity score-matched analysis

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  • Min-Chul Kim
  • Sung-Cheol Yun
  • Sang-Oh Lee
  • Sang-Ho Choi
  • Yang Soo Kim
  • Jun Hee Woo
  • Sung-Han Kim

Abstract

Objectives: Statins, which are lipid-lowering agents, have anti-inflammatory and immunomodulatory properties that may affect the occurrence of various infectious diseases. We assessed whether statins increase the risk of herpes zoster (HZ) with propensity score-matching. Methods: The study was based on the National Health Insurance database and its subset database of the “medical check-up” population of South Korea. These cohorts consist of about one million and 570,000 people, respectively, representative of the entire population of South Korea. We identified 103,930 statin users and 430,685 non-statin users. After propensity score-matching, 25,726 statin users and the same number of non-statin users were finally analyzed. The development of HZ was monitored in these matched pairs over the 11 years from 2003 to 2013. Results: Statin users had a significantly higher risk of HZ than non-statin users: hazard ratio (HR) 1.25 (95% CI, 1.15 to 1.37) (p

Suggested Citation

  • Min-Chul Kim & Sung-Cheol Yun & Sang-Oh Lee & Sang-Ho Choi & Yang Soo Kim & Jun Hee Woo & Sung-Han Kim, 2018. "Statins increase the risk of herpes zoster: A propensity score-matched analysis," PLOS ONE, Public Library of Science, vol. 13(6), pages 1-11, June.
    • Handle: RePEc:plo:pone00:0198263
    DOI: 10.1371/journal.pone.0198263
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