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Clinical outcomes and predictors of response to photodynamic therapy in symptomatic circumscribed choroidal hemangioma: A retrospective case series

Author

Listed:
  • Yeen-Fey Ho
  • Anne Chao
  • Kuan-Jen Chen
  • An-Ning Chao
  • Nan-Kai Wang
  • Laura Liu
  • Yen-Po Chen
  • Yih-Shiou Hwang
  • Wei-Chi Wu
  • Chi-Chun Lai
  • Tun-Lu Chen

Abstract

Background: To investigate the treatment outcomes and predictors of response to photodynamic therapy (PDT) in patients with symptomatic circumscribed hemangioma (CCH). Methods: This retrospective case series examined 20 patients with symptomatic CCH (10 submacular CCHs and10 juxtapapillary CCHs) who underwent standard PDT (wavelength: 662 nm; light dose: 50J/cm2; exposure time: 83 sec) with verteporfin (6mg/m2), either as monotherapy (n = 9) or in association with other treatments (n = 11), of which 7 received intravitreal injections (IVI) of anti-vascular endothelial growth factor (anti-VEGF). A post-PDT improvement of at least two lines in best-corrected visual acuity (BCVA) was the primary outcome measure. Predictors of response were investigated with binary logistic regression analysis. Results: Seventeen (85%) patients received one PDT session, and three patients (15%) underwent PDT at least twice. Ten patients (50%) achieved the primary outcome of a post-PDT BCVA improvement of at least two lines. Macular atrophy and recalcitrant cystoid macular edema in 2 patients. Binary logistic regression analysis revealed that younger age (

Suggested Citation

  • Yeen-Fey Ho & Anne Chao & Kuan-Jen Chen & An-Ning Chao & Nan-Kai Wang & Laura Liu & Yen-Po Chen & Yih-Shiou Hwang & Wei-Chi Wu & Chi-Chun Lai & Tun-Lu Chen, 2018. "Clinical outcomes and predictors of response to photodynamic therapy in symptomatic circumscribed choroidal hemangioma: A retrospective case series," PLOS ONE, Public Library of Science, vol. 13(5), pages 1-10, May.
    • Handle: RePEc:plo:pone00:0197088
    DOI: 10.1371/journal.pone.0197088
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