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The effectiveness of various computer-based interventions for patients with chronic pain or functional somatic syndromes: A systematic review and meta-analysis

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  • Miel A P Vugts
  • Margot C W Joosen
  • Jessica E van der Geer
  • Aglaia M E E Zedlitz
  • Hubertus J M Vrijhoef

Abstract

Computer-based interventions target improvement of physical and emotional functioning in patients with chronic pain and functional somatic syndromes. However, it is unclear to what extent which interventions work and for whom. This systematic review and meta-analysis (registered at PROSPERO, 2016: CRD42016050839) assesses efficacy relative to passive and active control conditions, and explores patient and intervention factors. Controlled studies were identified from MEDLINE, EMBASE, PsychInfo, Web of Science, and Cochrane Library. Pooled standardized mean differences by comparison type, and somatic symptom, health-related quality of life, functional interference, catastrophizing, and depression outcomes were calculated at post-treatment and at 6 or more months follow-up. Risk of bias was assessed. Sub-group analyses were performed by patient and intervention characteristics when heterogeneous outcomes were observed. Maximally, 30 out of 46 eligible studies and 3,387 participants were included per meta-analysis. Mostly, internet-based cognitive behavioral therapies were identified. Significantly higher patient reported outcomes were found in comparisons with passive control groups (standardized mean differences ranged between -.41 and -.18), but not in comparisons with active control groups (SMD = -.26 - -.14). For some outcomes, significant heterogeneity related to patient and intervention characteristics. To conclude, there is a minority of good quality evidence for small positive average effects of computer-based (cognitive) behavior change interventions, similar to traditional modes. These effects may be sustainable. Indications were found as of which interventions work better or more consistently across outcomes for which patients. Future process analyses are recommended in the aim of better understanding individual chances of clinically relevant outcomes.

Suggested Citation

  • Miel A P Vugts & Margot C W Joosen & Jessica E van der Geer & Aglaia M E E Zedlitz & Hubertus J M Vrijhoef, 2018. "The effectiveness of various computer-based interventions for patients with chronic pain or functional somatic syndromes: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 13(5), pages 1-27, May.
    • Handle: RePEc:plo:pone00:0196467
    DOI: 10.1371/journal.pone.0196467
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    1. Jogé Boumans & Aukelien Scheffelaar & Vera P. van Druten & Tessel H. G. Hendriksen & Lenny M. W. Nahar-van Venrooij & Andrea D. Rozema, 2021. "Coping Strategies Used by Older Adults to Deal with Contact Isolation in the Hospital during the COVID-19 Pandemic," IJERPH, MDPI, vol. 18(14), pages 1-19, July.
    2. Natalie A McNerney & Michael J Losensky & Madison M Lash & Kendal R Rozaieski & Daniela Ortiz & Alessandra N Garcia & Zachary D Rethorn, 2020. "Low theoretical fidelity hinders the research on health coaching for opioid reduction: A systematic review of randomized controlled trials," PLOS ONE, Public Library of Science, vol. 15(10), pages 1-15, October.
    3. Lina Braun & Yannik Terhorst & Ingrid Titzler & Johanna Freund & Janika Thielecke & David Daniel Ebert & Harald Baumeister, 2022. "Lessons Learned from an Attempted Pragmatic Randomized Controlled Trial for Improvement of Chronic Pain-Associated Disability in Green Professions: Long-Term Effectiveness of a Guided Online-Based Acc," IJERPH, MDPI, vol. 19(21), pages 1-24, October.

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