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Maternal vitamin D deficiency increases the risk of adverse neonatal outcomes in the Chinese population: A prospective cohort study

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  • Yuanliu Wang
  • Honghui Li
  • Min Zheng
  • Yubi Wu
  • Ting Zeng
  • Jinjian Fu
  • Dingyuan Zeng

Abstract

Background: Although vitamin D (vitD) deficiency is a common problem in pregnant women, in China, few studies have focused on the relationship between maternal vitD deficiency throughout the three trimesters and subsequent neonatal outcomes in China. Methods: Between 2015 and 2016, maternal serum and neonate cord blood samples were collected from 1978 mother-neonate pairs from Liuzhou city. Results: The mean concentrations of 25-hydroxy vitD (25(OH)D) were 16.17±6.27 and 15.23±5.43 ng/ml in the mother and neonate groups, respectively, and the prevalence values of vitD deficiency in the two groups were 78.18% and 83.27%, respectively. Logistic regression showed that maternal vitD deficiency independently increased the risk of gestational diabetes mellitus (GDM) (adjust OR, aOR 1.08; P = 0.026). A relatively lower risk of vitD deficiency was observed in the third trimester than in the first and second trimester (aOR 0.80; P = 0.004). VitD-calcium cosupplementation during pregnancy improves the vitD deficiency in both the maternal and neonatal groups (aOR 0.56, 0.66; P

Suggested Citation

  • Yuanliu Wang & Honghui Li & Min Zheng & Yubi Wu & Ting Zeng & Jinjian Fu & Dingyuan Zeng, 2018. "Maternal vitamin D deficiency increases the risk of adverse neonatal outcomes in the Chinese population: A prospective cohort study," PLOS ONE, Public Library of Science, vol. 13(4), pages 1-15, April.
    • Handle: RePEc:plo:pone00:0195700
    DOI: 10.1371/journal.pone.0195700
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