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A 50-50% mixture of nitrous oxide-oxygen in transrectal ultrasound-guided prostate biopsy: A randomized and prospective clinical trial

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Listed:
  • Gabriel da Silva Cazarim
  • Nubia Verçosa
  • Leonel Carneiro
  • Rachel Pastor
  • Elizabeth Fernandes Vaz da Silva
  • Louis Barrucand
  • Ismar Lima Cavalcanti

Abstract

Introduction: Transrectal ultrasound-guided biopsy (TUSPB) is the standard method of diagnosis for prostate cancer, and although it is well tolerated by some patients, it presents a discomfort rate of 65 to 90%, which may be associated with pain. For convenience, it is agreed that a method of analgesia and sedation is necessary. For this purpose, this study aimed to evaluate the impact of inhalation of a 50–50% N2O-O2 gas mixture on pain intensity in these patients. Material and methods: Randomized, double-blinded clinical trial, conducted at Antônio Pedro University Hospital (Hospital Universitário Antônio Pedro), Niterói, RJ, Brazil, containing two groups of 42 patients: a control (C) group, which received 100% oxygen inhalation, and a nitrous oxide (NO) group, which received inhalation of the 50–50% N2O-O2 mixture, self-administered during TUSPB. The pain intensity and degree of satisfaction were evaluated through a visual analogue scale (VAS), as was the frequency of adverse events. Results: Eighty-four patients were included in the study, with 42 in each group. The mean pain intensity was lower in the NO group than in the C group [2.52 (0–10) vs 5.95 (0–10), p

Suggested Citation

  • Gabriel da Silva Cazarim & Nubia Verçosa & Leonel Carneiro & Rachel Pastor & Elizabeth Fernandes Vaz da Silva & Louis Barrucand & Ismar Lima Cavalcanti, 2018. "A 50-50% mixture of nitrous oxide-oxygen in transrectal ultrasound-guided prostate biopsy: A randomized and prospective clinical trial," PLOS ONE, Public Library of Science, vol. 13(4), pages 1-10, April.
    • Handle: RePEc:plo:pone00:0195574
    DOI: 10.1371/journal.pone.0195574
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