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Evaluation of glycemic variability in chronic liver disease patients with type 2 diabetes mellitus using continuous glucose monitoring

Author

Listed:
  • Fumi Honda
  • Akira Hiramatsu
  • Hideyuki Hyogo
  • Hiroshi Aikata
  • Kana Daijo
  • Yuji Teraoka
  • Yuki Inagaki
  • Kei Morio
  • Tomoki Kobayashi
  • Takashi Nakahara
  • Yuko Nagaoki
  • Tomokazu Kawaoka
  • Masayasu Yoneda
  • Masataka Tsuge
  • Michio Imamura
  • Yoshiiku Kawakami
  • Hidenori Ochi
  • Kazuaki Chayama

Abstract

Background and aims: The feature of blood glucose dynamics in patients with chronic liver disease (CLD) is marked blood glucose fluctuations. However, the detail of blood glucose dynamics is not well known. The aim of the present study was to evaluate glycemic fluctuations by continuous glucose monitoring (CGM). Materials and methods: A total of 105 CLD patients with type 2 diabetes mellitus (T2DM) were enrolled in this study. Various parameters of glycemic variability were evaluated. The association of these parameters with liver functional reserve was examined. The parameters were also evaluated according to glycated hemoglobin A1c (HbA1c) levels. Results and discussion: Data of all patients showed that mean blood glucose (MBG) levels and the difference between highest and lowest blood glucose (ΔBG) increased significantly with worsening of liver functional reserve (P 145 mg/dL were higher in liver cirrhosis (LC) patients than in chronic hepatitis (CH) patients. In them, homeostasis model assessment for insulin resistance (HOMA-IR) of > 2.5 and LC were significantly associated with the increase in MAGE. LC was also significantly associated with increased MBG levels. Conclusion: The CGM systems were useful in finding hidden abnormalities of blood glucose fluctuations in CLD patients with T2DM, especially in non-anemic CLD patients with HbA1c levels of

Suggested Citation

  • Fumi Honda & Akira Hiramatsu & Hideyuki Hyogo & Hiroshi Aikata & Kana Daijo & Yuji Teraoka & Yuki Inagaki & Kei Morio & Tomoki Kobayashi & Takashi Nakahara & Yuko Nagaoki & Tomokazu Kawaoka & Masayasu, 2018. "Evaluation of glycemic variability in chronic liver disease patients with type 2 diabetes mellitus using continuous glucose monitoring," PLOS ONE, Public Library of Science, vol. 13(4), pages 1-13, April.
    • Handle: RePEc:plo:pone00:0195028
    DOI: 10.1371/journal.pone.0195028
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