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IL-17A, IL-17RC polymorphisms and IL17 plasma levels in Tunisian patients with rheumatoid arthritis

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Listed:
  • Tarak Dhaouadi
  • Mayssa Chahbi
  • Youssra Haouami
  • Imen Sfar
  • Leila Abdelmoula
  • Taieb Ben Abdallah
  • Yousr Gorgi

Abstract

Background: Interleukin-17 (IL-17), a cytokine mainly secreted by Th17 cells, seems to play a significant role in the pathogenesis of rheumatoid arthritis (RA). Functional genetic polymorphisms in IL-17 and its receptor genes can influence either qualitatively or quantitatively their functions. Therefore, we aimed to study the impact of IL17-A and IL17RC polymorphisms on plasma level of IL-17 and RA susceptibility and severity. Methods: In this context, IL-17A*rs2275913 and IL-17RC*rs708567 polymorphisms were investigated together with the quantification of IL17 plasma level in 115 RA patients and 91 healthy control subjects matched in age, sex and ethnic origin. Results: There were no statistically significant associations between IL-17A and IL-17RC studied polymorphisms and RA susceptibility. In contrast, IL-17A plasma levels were significantly higher in patients (55.07 pg/ml) comparatively to controls (4.75 pg/ml), p

Suggested Citation

  • Tarak Dhaouadi & Mayssa Chahbi & Youssra Haouami & Imen Sfar & Leila Abdelmoula & Taieb Ben Abdallah & Yousr Gorgi, 2018. "IL-17A, IL-17RC polymorphisms and IL17 plasma levels in Tunisian patients with rheumatoid arthritis," PLOS ONE, Public Library of Science, vol. 13(3), pages 1-11, March.
    • Handle: RePEc:plo:pone00:0194883
    DOI: 10.1371/journal.pone.0194883
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